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Posted On: 10/21/2022 10:25:39 PM
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Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, Functions and Therapeutic Potential
Yuan-YuanLiu1DaHuo1Lv-TaoZengGuo-QingFanTaoShenTie-MeiZhangJian-PingCaiJuCui
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, P.R. China
https://doi.org/10.1016/j.arr.2022.101763
Highlights
•
MANF’s activities: neurotrophic function; cell protection in non-neuronal tissues.
•
MANF protein levels decline with age in Drosophila, rodents, and humans.
•
MANF supplementation reverses age-related dysfunction and confers geroprotection.
•
MANF’s cellular protective effects demonstrate potential clinical application values.
Yuan-YuanLiu1DaHuo1Lv-TaoZengGuo-QingFanTaoShenTie-MeiZhangJian-PingCaiJuCui
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, P.R. China
https://doi.org/10.1016/j.arr.2022.101763
Highlights
•
MANF’s activities: neurotrophic function; cell protection in non-neuronal tissues.
•
MANF protein levels decline with age in Drosophila, rodents, and humans.
•
MANF supplementation reverses age-related dysfunction and confers geroprotection.
•
MANF’s cellular protective effects demonstrate potential clinical application values.
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