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Posted On: 07/04/2022 9:08:37 AM
Post# of 153889
Thank you so much ohm.
Yes, you're right. The transgene does not get integrated into the DNA.
That's good, because otherwise, that could lead to mutations and production of faulty leronlimab.
Rather, the transgene remains in the cytoplasm of the T and B cells producing leronlimab as it is triggered to do so and when it comes time to divide that T or B cell via mitosis, the transgene is also replicated and becomes a part of the cytoplasm of the daughter cells and performs the same task of producing leronlimab via ribosomes and the ER, based on triggering stimulus.
The genetic material does not have a half life, it just lasts and lasts. So it is used over and over in the cytoplasm and then it will be copied via mitosis when it comes time for the T or B cells to divide.
This is a beautiful solution and hope it proves successful
Yes, you're right. The transgene does not get integrated into the DNA.
That's good, because otherwise, that could lead to mutations and production of faulty leronlimab.
Rather, the transgene remains in the cytoplasm of the T and B cells producing leronlimab as it is triggered to do so and when it comes time to divide that T or B cell via mitosis, the transgene is also replicated and becomes a part of the cytoplasm of the daughter cells and performs the same task of producing leronlimab via ribosomes and the ER, based on triggering stimulus.
The genetic material does not have a half life, it just lasts and lasts. So it is used over and over in the cytoplasm and then it will be copied via mitosis when it comes time for the T or B cells to divide.
This is a beautiful solution and hope it proves successful
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