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Only when both of these biomarker/labs fail to increase from one period to the next should LL be stopped because when both fail to increase, LL is no longer functional because the patient's condition has improved so much that the giving of LL has essentially become equal to the giving of Placebo causing no effect on liver steatosis or fibrosis.

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Failing to increase just means the disease has stabilized with leronlimab treatment. Removing treatment may mean reverting to disease progression.

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