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Posted On: 06/21/2022 10:32:15 PM
Post# of 148888
Re: thriftycents #125141
I wished they had actual numbers over time rather than that heat map. But numbers over time would have never fit on a poster. For chemistry, CK-18, Fibro test, Lipids and Pro-Inflammatories at 350mg things for the most part are going in the direction you want them too. For the 700mg they are fairly weak.
What really caught my eye is the astonishingly large difference in Pro-Inflammatories between 350mg and 700mg. The level of blockade would correspond to a more pronounced drop in level of those chemokines. At 700mg you're seeing a very mild decrease to an actual increase. At 350mg it's a substantially better result. What is even more telling is a reduction in the CCL2, CCL3, CCL5 (RANTES) and CCL18 ligands in 350mg but not in 700mg. There must be something terribly wrong in how that 700mg trial was either set up or run.
What really caught my eye is the astonishingly large difference in Pro-Inflammatories between 350mg and 700mg. The level of blockade would correspond to a more pronounced drop in level of those chemokines. At 700mg you're seeing a very mild decrease to an actual increase. At 350mg it's a substantially better result. What is even more telling is a reduction in the CCL2, CCL3, CCL5 (RANTES) and CCL18 ligands in 350mg but not in 700mg. There must be something terribly wrong in how that 700mg trial was either set up or run.
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