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Posted On: 06/09/2022 12:51:38 PM
Post# of 148878
aplaviroc and vicriviroc - new to me
wikipedia
aplaviroc - GSK - all studies of aplaviroc were discontinued due to liver toxicity
vicriviroc - Merck - decided to not pursue regulatory approval for use in treatment-experienced patients because the drug did not meet primary efficacy endpoints in late stage trials. Clinical trials continue in patients previously untreated for HIV
and of course
maraviroc - can cause serious, life-threatening side effects. These include liver problems, skin reactions, and allergic reactions. An allergic reaction may happen before liver problems occur. Official labeling of Selzentry has BLACK BOX warning for hepatotoxicity. (although) The MOTIVATE trials showed no clinically relevant differences in safety between the maraviroc and placebo groups. CCR5 drugs may facilitate the emergence of resistant strains of HIV-1.... maraviroc-resistant variants of HIV-1 have already been generated in vitro by mutating residues in the V3 loop of gp120
leronlimab looking good in this group
wikipedia
aplaviroc - GSK - all studies of aplaviroc were discontinued due to liver toxicity
vicriviroc - Merck - decided to not pursue regulatory approval for use in treatment-experienced patients because the drug did not meet primary efficacy endpoints in late stage trials. Clinical trials continue in patients previously untreated for HIV
and of course
maraviroc - can cause serious, life-threatening side effects. These include liver problems, skin reactions, and allergic reactions. An allergic reaction may happen before liver problems occur. Official labeling of Selzentry has BLACK BOX warning for hepatotoxicity. (although) The MOTIVATE trials showed no clinically relevant differences in safety between the maraviroc and placebo groups. CCR5 drugs may facilitate the emergence of resistant strains of HIV-1.... maraviroc-resistant variants of HIV-1 have already been generated in vitro by mutating residues in the V3 loop of gp120
leronlimab looking good in this group
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