Excerpt: "We found that the expression of CCR5 and its ligands were anticorrelated with BAP1 (figure 1A). Additionally, patients with higher expression of CCR5 and its ligands were at greater risk of death (figure 1B). Real-time PCR analysis confirmed this in BAP1-mutant patients with ccRCC (figure 1C). IHC analysis further revealed that BAP1 protein was negatively associated with CCR5 and its ligands (figure 1D-E). Next, we stably integrated an RNA interference vector into murine RENCA cells and established a BAP1 knockdown cell line, which was then used to construct a subcutaneous tumor-bearing mouse model. Flow cytometry and ELISA results showed that the proportion of CCR5+ cells and the expression levels of CCL2, CCL3 and CCL5 in ccRCC tumors were higher than those in the control group (figure 1F). These results indicated the association existing between BAP1 gene mutation and high expression of CCR5 and its ligands."

I'm not a science guy by any measure. So, I am intrigued and puzzled by the enormous big pharma quietude surrounding LL. All uniformly express no interest whatsoever in LL. There are no existing clues anywhere of even a mild case of big pharma curiosity about LL. There is absolute silence everywhere you look beyond the close and noisy confines of the LL shareholder community.

Which brings me to my personal problem. I know I can have a science related handicap. As such, I know, on my own, I can easily be traveling down a wrong headed path re: LL's prospects. But I don't think I am. I think I am living in an investment/science/pharma environment of manufactured silence concerning LL's potential. It is just too quiet to be true.

Papers/studies/scientists like the one cited above are just too, too numerous and too CCR specific to be blissfully and continually ignored by big pharma as coincidence, wrong or off point. They are just too many scientifically potent indications and vindications of LL's MoA authored and read by too many smart people to justify the current silence. IMO its a fake silence. Something is afoot.