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Posted On: 06/01/2022 8:43:44 PM
Post# of 148892
MGK underscore 2 wrote, in response to Ohm20:
"This last statement:
You also seem to be unaware that cells have life cycles and leronlimab can bind to new cells as they form and the older ones that are already bound with chemokines will die off.
is untrue and not applicable.
If we have to wait for the immune system to regenerate before LL works, this investment is worthless.
First, thank you for being a member of the board. It's the best one. You chose wisely.
But second, I feel like for all the information you dump into posts there are some glaring moments of confusion for me. One was when you discussed Nash results and proposed a linear relationship between dose and result for not just LL, but seemingly for all drugs. Which is absolutetly not how most drug doses work.
Another is the comment I quoted above.
It reads like you believe the body has a finite number of cells and actions. Things regenerate, drugs leave the body at various rates for various reasons. A receptor blocked today might not be blocked tomorrow. For instance there are more than one muscarinic receptors (M1-M5) located in various parts of the body, and blocking one versus another can have a wildly different effect. As can how you try to dose your anti-muscarinic, be it inhaled, injected, delivered transdermally, or wafted in your general direction by Tibetan Monks.
I think it was Ken Chowder, our boards #1 soup-based poster, who said something about your optimism and facts not always aligning the way you think they do. It seems fair. I like your enthusiasm though I do question some of the science or facts you lay out.
I guess what I'm mainly saying is that I think you may be the lovechild of Goosebumps and JLang.
Could you please confirm or deny this. It's been weighing heavily on my mind.
Thank you.
And keep posting.
"This last statement:
You also seem to be unaware that cells have life cycles and leronlimab can bind to new cells as they form and the older ones that are already bound with chemokines will die off.
is untrue and not applicable.
If we have to wait for the immune system to regenerate before LL works, this investment is worthless.
First, thank you for being a member of the board. It's the best one. You chose wisely.
But second, I feel like for all the information you dump into posts there are some glaring moments of confusion for me. One was when you discussed Nash results and proposed a linear relationship between dose and result for not just LL, but seemingly for all drugs. Which is absolutetly not how most drug doses work.
Another is the comment I quoted above.
It reads like you believe the body has a finite number of cells and actions. Things regenerate, drugs leave the body at various rates for various reasons. A receptor blocked today might not be blocked tomorrow. For instance there are more than one muscarinic receptors (M1-M5) located in various parts of the body, and blocking one versus another can have a wildly different effect. As can how you try to dose your anti-muscarinic, be it inhaled, injected, delivered transdermally, or wafted in your general direction by Tibetan Monks.
I think it was Ken Chowder, our boards #1 soup-based poster, who said something about your optimism and facts not always aligning the way you think they do. It seems fair. I like your enthusiasm though I do question some of the science or facts you lay out.
I guess what I'm mainly saying is that I think you may be the lovechild of Goosebumps and JLang.
Could you please confirm or deny this. It's been weighing heavily on my mind.
Thank you.
And keep posting.
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