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Posted On: 05/27/2022 4:40:25 AM
Post# of 148902
home run ohm. Thank you so much.
Pfizer will do as well as Gilead did.
The criteria for NAFLD are 2-3 of the following: (they are very similar to the criteria for Metabolic Syndrome);
Central Obesity waist circumference > 102cm men or 88cm women, BMI > 30
Triglycerides > 150
HDL cholesterol <40 in men; <50 in women
Hypertension >140
Glucose > 100
Microalbuminuria: albumin-creatinine ratio > 30
Both Triglycerides and HDL are lipids.
By taking a drug which increases lipids, you are in fact inducing NAFLD, and you could also be inducing Metabolic Syndrome, not to mention going against the great majority of cardiologist recommendations and protocols for cholesterol management. What cardiologist would want to prescribe a medication with the potential of increasing lipids?
What do people die of in NASH? 38% die of cardiovascular diseases. 19% die of non-liver cancer. 8% die of cirrhosis complications, 1% die of Hepatocellular carcinoma; 8% die of infections. <1% die of liver transplant.
the rest is other.
Elevated lipids leads to cardiovascular disease which has significant morbidity and mortality associated with Metabolic Syndrome. Do you want to risk that to reduce liver fat? Doesn't seem logical.
Big pharma loves keeping the status quo of disease. After all, without disease, there is no Big Pharma.
Resmetirom - selective thyromimetic, which selectively improves the hypothyroid state of the liver only, is more of a competitor to LL than the ACC inhibitor / DGAT2 inhibitor combo.
Remember those small percent losses in weight leading to big improvements in NAS score? No, the drug they propose gets rid of the fat by increasing lipids. How long will that last? When you stop taking the drug, the fat comes back because it is not operating at the root of the problem. Better off eating a Mediterranean diet & doing activity, lay off the carbs, the foods which increase lipids. Not according to Big Pharma, they have you taking meds which can significantly increase lipids.
I guess they also want you to double your dose of Statins. That would be another way to induce a counter effect on the drug they propose.
Pfizer will do as well as Gilead did.
The criteria for NAFLD are 2-3 of the following: (they are very similar to the criteria for Metabolic Syndrome);
Central Obesity waist circumference > 102cm men or 88cm women, BMI > 30
Triglycerides > 150
HDL cholesterol <40 in men; <50 in women
Hypertension >140
Glucose > 100
Microalbuminuria: albumin-creatinine ratio > 30
Both Triglycerides and HDL are lipids.
By taking a drug which increases lipids, you are in fact inducing NAFLD, and you could also be inducing Metabolic Syndrome, not to mention going against the great majority of cardiologist recommendations and protocols for cholesterol management. What cardiologist would want to prescribe a medication with the potential of increasing lipids?
What do people die of in NASH? 38% die of cardiovascular diseases. 19% die of non-liver cancer. 8% die of cirrhosis complications, 1% die of Hepatocellular carcinoma; 8% die of infections. <1% die of liver transplant.
the rest is other.
Elevated lipids leads to cardiovascular disease which has significant morbidity and mortality associated with Metabolic Syndrome. Do you want to risk that to reduce liver fat? Doesn't seem logical.
Big pharma loves keeping the status quo of disease. After all, without disease, there is no Big Pharma.
Resmetirom - selective thyromimetic, which selectively improves the hypothyroid state of the liver only, is more of a competitor to LL than the ACC inhibitor / DGAT2 inhibitor combo.
Remember those small percent losses in weight leading to big improvements in NAS score? No, the drug they propose gets rid of the fat by increasing lipids. How long will that last? When you stop taking the drug, the fat comes back because it is not operating at the root of the problem. Better off eating a Mediterranean diet & doing activity, lay off the carbs, the foods which increase lipids. Not according to Big Pharma, they have you taking meds which can significantly increase lipids.
I guess they also want you to double your dose of Statins. That would be another way to induce a counter effect on the drug they propose.
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