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Posted On: 05/11/2022 11:07:07 PM
Post# of 154140
For 50% dosing NASH, 350mg, they had:
80% of the patients had a 50ms drop and 50% of the patients had 80ms drop average.
What are the guesses for full dosing at 700mg?
The following would be a linear extrapolation. Doubling the dosage doubles the performance.
80% of the patients have 100ms drop and 50% of the patients have 160ms drop average.
If this is what happens, effectively, we reduce NASH by 6 NAS levels. The worst NAS level is 8. The worst case of NASH, NAS 8 may be reduced to a NAFLD level of 2.
A NASH case of 6 is taken down to a healthy liver.
That is the implications of a linear extrapolation. I say it will be better than linear. I say:
80% of the patients have 126ms drop and 50% of the patients have 180ms drop average.
That eradicates 8 levels of NAS curing even the worst case of NASH.
This is what I see coming.
80% of the patients had a 50ms drop and 50% of the patients had 80ms drop average.
What are the guesses for full dosing at 700mg?
The following would be a linear extrapolation. Doubling the dosage doubles the performance.
80% of the patients have 100ms drop and 50% of the patients have 160ms drop average.
If this is what happens, effectively, we reduce NASH by 6 NAS levels. The worst NAS level is 8. The worst case of NASH, NAS 8 may be reduced to a NAFLD level of 2.
A NASH case of 6 is taken down to a healthy liver.
That is the implications of a linear extrapolation. I say it will be better than linear. I say:
80% of the patients have 126ms drop and 50% of the patients have 180ms drop average.
That eradicates 8 levels of NAS curing even the worst case of NASH.
This is what I see coming.
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