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Brilacidin is a novel mimetic of defensin, which is also known as PMX30063, which has been fast tracked by the Federal Drug Administration (FDA) for the treatment of oral mucositis [170]. A recent study has demonstrated the potent antiviral activity of Brilacidin against SARS-CoV-2. It prevents viral entry into the hosts cells by interacting with ACE2 receptors and disrupting viral integrity [171]. HDPs can also be used in combination with other antiviral treatments. Drugs such as remdesivir have shown effectiveness in reducing the recovery time of COVID patients and reduce the risk of further progression [172]. Bakovic et al. demonstrated the efficacy of combining remdesivir with Brilacidin and the data showed that the inhibition profile of this combination treatment was greater than using both compounds alone; notably, a synergistic inhibition of >99% was reported [171]. Currently, Brilacidin is being tested under phase II clinical trials for the treatment of SARS-CoV-2 infection (clinicaltrials.gov identifier: NCT04784897).

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