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meaningful improvements in leronlimab over placebo were observed for cough, stuffy/runny nose, shortness of breath, tightness of chest, feeling of fast heartbeat, fatigue, muscle aches/cramps, muscle weakness, joint pain/swelling, chills/shivering, feeling hot or feverish, difficulty in concentration, sleep disturbance/insomnia, headache, dizziness, tingling/numbness, sense of taste, and sense of smell. Of the remaining 6 symptoms, sore throat, exertional malaise, anxiety, nausea, and vomiting had no clinically meaningful change.

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You can see how this might be hard to translate into a rigorous protocol. Leron improved "shortness of breath," feeling of fast heartbeat," "muscle aches," "dizziness" and "Fatigue," but it didn't help "exertional malaise." I don't know about you, but when I exert myself too much, my malaise usually takes the form of things like shortness of breath, dizziness, fast heartbeat, muscle aches and fatigue. So how did Leron help the latter symptoms but not the former one? Could it be that patients didn't know what "malaise" meant? What exertional malaise could you get that didn't show itself in some of the symptoms Leron helped?

And how do we really know what caused the anxiety that Leron didn't help? If you were a longhauler who lost their job, Leron might not cure your anxiety....