IMHO, highly unlikely many who came in at the top have held all the way down, but we have all read posts from those like myself that came in between $5 - $7. I had some tough moments convincing myself to hang in there, even as convinced as I was about the science behind this molecule. I ended up adding 40% more shares as I cost averaged down to the low $2's, by then, too invested to bail. My last additions were another 60% of total shares held at a little over $1 and now holding at nearly 250% from my original buy in. My average is a little over 50% of that first batch. It really doesn't matter what the sp average is if we get any of the following:

1. ANY approval
2. Partner who will provide the heft we need so badly to launch

3. Buyout offer that is enough to satisfy a majority of shareholders (actually majority of shares held, not necessarily majority of shareholders)

My personal preference is as numbered, would love to be around for that 3 digit share price at the very least.