dwfl,

Thanks for sharing. Here is the original article, which demonstrates unequivocally that covid dose infect the brain and a range of extrapulmonary tissues.

SARS-CoV-2 infection and persistence throughout the human body and brain

https://assets.researchsquare.com/files/rs-11...1640020576

A couple of highlights which I found interesting.

Quote:

---

Phases of diffuse alveolar damage showed clear temporal associations, with the exudative phase seen mainly within the first three weeks of infection and the fibrosing phase not seen until after a month of infection

---

This indicates a longer window of opportunity for leronlimab to help critical covid patients. I have concern that any therapy will effectively reverse pulmonary fibrosis. I don't believe that pulmonary tissues are regenerated as readily as hepatic tissue.

Perhaps Kabonk can shed some light.

Quote:

---

Our findings, therefore, suggest viremia leading to body-wide dissemination, including across the blood-brain barrier, and viral replication can occur early in COVID-19, even in asymptomatic or mild cases.

---

Quote:

---

Further, persistence of low-level SARS-CoV-2RNA (0.0004 to <0.5 N gene copies/ng RNA input) was frequently detected across multiple tissue categories among all late cases, despite being undetectable in plasma (Extended Data Fig.2, Supplementary Data 1). Notably, SARS-CoV-2 RNA was detected in the brains of all six late cases and across most locations evaluated in the brain in five of these six, including P42 who died at D230

---

Viral reproduction occurs early in the disease course in multiple organs, but continues to reproduce locally even after resolution of viremia. The authors found viral reproduction in tissues at day 99 in one patient.

The ability of leronlimab to cross the BBB becomes ever more important.

Thanks again for sharing.