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Posted On: 12/17/2021 7:14:25 AM
Post# of 148899
Jlang,
I don’t appreciate the personal attacks. Your arguments are not bolstered y attacking others, yet you persist. I don’t claim to be a scientist, just an observer of information presented by others.
I did not support Dr. Patterson’s alignment with the 13D, but his paper from May 2020 describing the effect of Leronlimab in Dr. Seethamraju’s patients is unimpeachable.
I do not believe I made a single post referencing any new information from Dr. Patterson since his release of his paper on PASC, about which I expressed doubts as it was based on machine learning, fitting a model to historical data and did not evaluate interventions.
Here is the abstract from the critical covid treatment paper, for those who have not read it, or reviewed it recently. It remains a great explanation of Leronlimab in covid, especially his analysis of altered RNA transcriptions (down regulation/downstream effects)
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
[q] Here, in 10 terminally-ill, critical COVID-19 patients we report profound elevation of plasma IL-6 and CCL5 (RANTES), decreased CD8+ T cell levels, and SARS-CoV-2 plasma viremia. Following compassionate care treatment with the CCR5 blocking antibody leronlimab, we observed complete CCR5 receptor occupancy on macrophage and T cells, rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia. Consistent with reduction of plasma IL-6, single-cell RNA-sequencing revealed declines in transcriptomic myeloid cell clusters expressing IL-6 and interferon-related genes.[/q]
https://pubmed.ncbi.nlm.nih.gov/32511656/
The theory of omicron emergence from mice is just one of many.
[q]Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting the possibility of host-jumping. The molecular spectrum (i.e., the relative frequency of the twelve types of base substitutions) of mutations acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients, but was highly consistent with spectra associated with evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.[/q]
No one knows the origin with certainty. I will offer that is was produced by actual scientists, listed here:
Changshuo Wei, Ke-Jia Shan, Weiguang Wang, Shuya Zhang, Qing Huan, View ORCID ProfileWenfeng Qian
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
https://www.biorxiv.org/content/10.1101/
Dr Patterson is not among them.
I don’t appreciate the personal attacks. Your arguments are not bolstered y attacking others, yet you persist. I don’t claim to be a scientist, just an observer of information presented by others.
I did not support Dr. Patterson’s alignment with the 13D, but his paper from May 2020 describing the effect of Leronlimab in Dr. Seethamraju’s patients is unimpeachable.
I do not believe I made a single post referencing any new information from Dr. Patterson since his release of his paper on PASC, about which I expressed doubts as it was based on machine learning, fitting a model to historical data and did not evaluate interventions.
Here is the abstract from the critical covid treatment paper, for those who have not read it, or reviewed it recently. It remains a great explanation of Leronlimab in covid, especially his analysis of altered RNA transcriptions (down regulation/downstream effects)
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
[q] Here, in 10 terminally-ill, critical COVID-19 patients we report profound elevation of plasma IL-6 and CCL5 (RANTES), decreased CD8+ T cell levels, and SARS-CoV-2 plasma viremia. Following compassionate care treatment with the CCR5 blocking antibody leronlimab, we observed complete CCR5 receptor occupancy on macrophage and T cells, rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia. Consistent with reduction of plasma IL-6, single-cell RNA-sequencing revealed declines in transcriptomic myeloid cell clusters expressing IL-6 and interferon-related genes.[/q]
https://pubmed.ncbi.nlm.nih.gov/32511656/
The theory of omicron emergence from mice is just one of many.
[q]Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting the possibility of host-jumping. The molecular spectrum (i.e., the relative frequency of the twelve types of base substitutions) of mutations acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients, but was highly consistent with spectra associated with evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.[/q]
No one knows the origin with certainty. I will offer that is was produced by actual scientists, listed here:
Changshuo Wei, Ke-Jia Shan, Weiguang Wang, Shuya Zhang, Qing Huan, View ORCID ProfileWenfeng Qian
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
https://www.biorxiv.org/content/10.1101/
Dr Patterson is not among them.
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