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Posted On: 11/07/2021 10:50:51 AM
Post# of 72444

Re: rockyracoon #70759
Recent Brilacidin studies - break it down:
A: Dual Activity==
Mechanistic studies revealed that brilacidin has a dual antiviral mechanism of action including ,
1. virucidal activity and
2. binding to coronavirus attachment factor HSPGs on host cell surface.
B: Understanding host targets:
Brilacidin partially loses its antiviral activity when heparin was included in the cell cultures, supporting the host-targeting mechanism.
(Key words: partially and blood thinners. )
( perhaps one of our Docs can shed more light here )
Q: what is heparin? See below
Drug combination therapy:
C:Why Remdisavir & Brilacidin?
Drug combination therapy showed that brilacidin has a strong synergistic effect with remdesivir against HCoV-OC43 in cell culture. Taken together, this study provides appealing findings for the translational potential of brilacidin as a broad-spectrum antiviral for coronaviruses including SARS-CoV-2.
HEPARIN:
Heparin is used to treat and prevent blood clots caused by certain medical conditions or medical procedures. It is also used before surgery to reduce the risk of blood clots.
A: Dual Activity==
Mechanistic studies revealed that brilacidin has a dual antiviral mechanism of action including ,
1. virucidal activity and
2. binding to coronavirus attachment factor HSPGs on host cell surface.
B: Understanding host targets:
Brilacidin partially loses its antiviral activity when heparin was included in the cell cultures, supporting the host-targeting mechanism.
(Key words: partially and blood thinners. )
( perhaps one of our Docs can shed more light here )
Q: what is heparin? See below
Drug combination therapy:
C:Why Remdisavir & Brilacidin?
Drug combination therapy showed that brilacidin has a strong synergistic effect with remdesivir against HCoV-OC43 in cell culture. Taken together, this study provides appealing findings for the translational potential of brilacidin as a broad-spectrum antiviral for coronaviruses including SARS-CoV-2.
HEPARIN:
Heparin is used to treat and prevent blood clots caused by certain medical conditions or medical procedures. It is also used before surgery to reduce the risk of blood clots.


Ronald A Phillips
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