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Posted On: 10/28/2021 8:52:00 AM
Post# of 154686
For those like me who struggle to appreciate the multiple and unexpected manifestations of Covid, here is the best article I have seen describing the multiple components of Covid pathology.
Macrophages key to pulmonary injury and a large part of coagulopathy. Macrophage polarization and trafficking blocked by Leronlimab. A lot of information crammed into this, but it does not require a profound level of knowledge to appreciate the discussion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...n_sectitle
A scoping review of the pathophysiology of COVID-19
“ COVID-19 disease can be considered to be the connection of three basic pathologic processes, namely a pulmonary macrophage activation syndrome with uncontrolled inflammation, a complement-mediated endothelialitis together with a procoagulant state with a thrombotic microangiopathy. In addition, platelet activation with the release of serotonin and the activation and degranulation of mast cells contributes to the hyper-inflammatory state. ”
Macrophages key to pulmonary injury and a large part of coagulopathy. Macrophage polarization and trafficking blocked by Leronlimab. A lot of information crammed into this, but it does not require a profound level of knowledge to appreciate the discussion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...n_sectitle
A scoping review of the pathophysiology of COVID-19
“ COVID-19 disease can be considered to be the connection of three basic pathologic processes, namely a pulmonary macrophage activation syndrome with uncontrolled inflammation, a complement-mediated endothelialitis together with a procoagulant state with a thrombotic microangiopathy. In addition, platelet activation with the release of serotonin and the activation and degranulation of mast cells contributes to the hyper-inflammatory state. ”
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