Surprise! Something that's NOT an amyloid theory drug seems to have some efficacy at preventing Alzheimer's.

https://www.statnews.com/2021/10/11/mouse-exp...-152820318

Quote:

---

A generic drug used widely to treat swelling associated with hypertension and heart failure showed hints in early research that it may also prevent the devastating brain damage of Alzheimer’s disease, a surprising twist that suggests scientists have a lot more to learn about the root cause of the neurodegenerative condition.

The findings, reported Monday in Nature Aging, show how the drug, bumetanide, reversed signs of Alzheimer’s in mice, as well as in human brain cells in lab dishes. The new study also detailed real-world data mined from millions of patients’ electronic health records showing that people over the age of 65 who regularly took bumetanide were 35% to 75% less likely to be diagnosed with Alzheimer’s.

---