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Posted On: 10/02/2021 3:58:03 AM
Post# of 148936
smurph,
Very cool find. I was not aware of this CCR5 antagonist.
Lithospermum Erythrorhizon derived shikonin , in addition to down-regulating CCR5 cell surface expression, also down-regulates CCL5/RANTES (or at least the mouse model equivalent, mRANTES).
https://www.spandidos-publications.com/10.389...8/download
Additionally:
Advances in Botanical Research
Volume 62, 2012, Pages 197-272
Developing Phytocompounds from Medicinal Plants as Immunomodulators
https://www.sciencedirect.com/science/article...5914000040
Very cool find. I was not aware of this CCR5 antagonist.
Lithospermum Erythrorhizon derived shikonin , in addition to down-regulating CCR5 cell surface expression, also down-regulates CCL5/RANTES (or at least the mouse model equivalent, mRANTES).
Quote:
mRANTES levels in the peritoneal fluid of the animal endometriosis model ... decreased significantly following shikonin treatment in a dose‐dependent manner (P<0.05)
https://www.spandidos-publications.com/10.389...8/download
Additionally:
Quote:
shikonin significantly inhibited the early expression (within 0.5 h) of approximately 50 genes, notably cytokines TNF-α, IL-1β and IL-4, chemokines CCL4 and CCL8 and inflammatory modulators NFATC3 and PTGS2
Advances in Botanical Research
Volume 62, 2012, Pages 197-272
Developing Phytocompounds from Medicinal Plants as Immunomodulators
https://www.sciencedirect.com/science/article...5914000040
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