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Dr. Vanden Bossche makes many points, so I’ve tried to distill some of the most important:

Prevention and containment measures coupled with vaccinating such a large proportion of the population in a manner that doesn’t guarantee elimination of the virus, encourages selective viral ‘immune escape’ where viruses continue to be shed from those who are infected because neutralizing antibodies have failed to prevent replication and elimination of the virus.
The evolutionary selection pressure on the virus will, through ‘immune escape,’ create ever more virulent strains of the virus that have a competitive advantage over other variants and will increasingly have the potential to break through the antibody defences provided by the adaptive immune system, so inducing ‘vaccine resistance.’ Because the current vaccines attempt to train only the adaptive immune system that is highly specific to particular strains, vaccine makers will all the time find themselves on the backfoot as new mutant strains outsmart the vaccines.

The only possibility of eradicating these more virulent strains is via particular white blood cells (lymphocytes) in the innate immune system, namely natural killer (NK) cells. This Vanden Bossche evidences from knowledge that those who are asymptomatic (e.g. most children) are able to eliminate infection at a very early stage of infection through the enhanced function of the innate (‘first response’) immune system at the mucosal surfaces of the airways. Vanden Bossche argues nearly all of the deactivation of viruses occurs through the action of NK cells that are polyspecific by nature, because they eliminate the cells infected with the virus so affecting all variants or mutants of the virus.
The worst of the pandemic is still to come. Bossche argues we are now experiencing the calm before the storm. Vanden Bossche predicts the next wave of infection will be dramatic — far worse than anything we’ve seen to-date. This is because there will be more mutants to which the adaptive immune system provides little resistance, and this will come at the expense of decreased innate immune effectiveness. While he mentions that NK cell-based vaccines, which he claims to have been researching for the last decade or so but about which he also says he has no commercial interest, are the ultimate solution, he believes it is likely too late to escape the storm.

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