Which cells are you getting your data from? T effectors or T regs, they are different. Is there a major difference in clinical efficacy between 85 and 90% occupancy or is that just your theoretical postulation. Are you aware that in vitro mav binds with a higher affinity than LL and has the ability to displace LL off the receptor? It may even be a disadvantage to have 100% occupancy of LL on T effectors to the patient.