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Posted On: 09/23/2021 12:28:57 PM
Post# of 157736
Re: KenChowder #105279
Study excerpts: "..., CCR5 is a translational target for neural repair in stroke and TBI and the first reported gene associated with enhanced recovery in human stroke"
"... While the biology of neural repair in adult brain injuries such as stroke and TBI is increasingly defined (Grafman and Salazar, 2015), there have been no medical therapies developed to promote recovery in these" injuries.
""... As stroke induces neuronal expression of CCR5, and increased CCR5 signaling is associated with reduced learning and memory (Zhou et al., 2016), we examined if neuron-specific knockdown of CCR5 in pre-motor cortex promotes stroke recovery. Neuronal plasticity in pre-motor-to-motor circuits after stroke in motor cortex is causally associated with motor recovery (Clarkson et al., 2010, 2011; Overman et al., 2012; Li et al., 2015).
https://www.cell.com/cell/pdf/S0092-8674(19)30107-2.pdf
"... While the biology of neural repair in adult brain injuries such as stroke and TBI is increasingly defined (Grafman and Salazar, 2015), there have been no medical therapies developed to promote recovery in these" injuries.
""... As stroke induces neuronal expression of CCR5, and increased CCR5 signaling is associated with reduced learning and memory (Zhou et al., 2016), we examined if neuron-specific knockdown of CCR5 in pre-motor cortex promotes stroke recovery. Neuronal plasticity in pre-motor-to-motor circuits after stroke in motor cortex is causally associated with motor recovery (Clarkson et al., 2010, 2011; Overman et al., 2012; Li et al., 2015).
https://www.cell.com/cell/pdf/S0092-8674(19)30107-2.pdf
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