Systemic toxicity of AE37, 28 grade 0, 58 grade 1, 12 grade 2 and 1 grade 3 (e.g. requiring hospitalisation). This can be attributed to the immunoadjuvant. So, even the potential complete vaccine would have adverse effects. Maybe the long term effects are better known.

It looks like a few percents of individuals have Grade 3 effects with Pfizer