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Posted On: 06/21/2021 9:59:52 AM
Post# of 145873
AVXL just had good trial results in Rett syndrome a genetic neurological disorder.
I posted this over at stocktwits -
I posted this over at stocktwits -
Quote:
I was wondering why someone asked me if Sigma 1 (aka Sigmar 1) would enhance leronlimab's effectiveness. Anavex2-73 is a Sigma 1 agonist that lowers CA2+ influx.
Here's what I answered -
"Excessive CA2+ (calcium) leads to protein misfolding. Leronlimab downregulates CA2+ so a Sigma 1 agonist would add nothing."
Then of course you have the anti-inflammatory effects of leronlimab.
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