AVXL just had good trial results in Rett syndrome a genetic neurological disorder.

I posted this over at stocktwits -

Quote:

---

I was wondering why someone asked me if Sigma 1 (aka Sigmar 1) would enhance leronlimab's effectiveness. Anavex2-73 is a Sigma 1 agonist that lowers CA2+ influx.

Here's what I answered -
"Excessive CA2+ (calcium) leads to protein misfolding. Leronlimab downregulates CA2+ so a Sigma 1 agonist would add nothing."

Then of course you have the anti-inflammatory effects of leronlimab.

---