Many sc meds are weight dependent, but I'm not sure why LL is administered that way (other than the fact that it is very safe/non toxic). I'm not aware of any reason a clinician would assume that a 105lb woman would need 15mg/kg while a heavier person would only need 7.5mg/kg. While endless RO studies might lead to some different answers(based on many up regulation/down regulation conditions or even differences between male and female biochemistry similar to alcohol dehydrogenase levels), I'm not aware of any info/papers about LL that answers that. Good question though, IMO.