They did build in a buffer. They requested 4 doses since a lot of the EIND patients were treated with 4. The FDA said no, you are using 2 in the mild/moderate trial, use the same here. They were handicapped from the outset.

I think other countries are figuring it out though. Their doctors can tell Remdesivir is not working. It will be replaced. Hopefully with Leronlimab.