Yes, people do respond differently in some ways to the covid19 virus, and also to the treatments. Dr Bruce Patterson, Dr Yo on youtube and Dr Been on youtube and their guests, have often emphasized that "timing" of covid19 drugs "can be" (not always) critical. For example, remdesivir can display efficacy if given to m/m cv19 patients, but it's efficacy is nominal or undetectable (other than side effects) for most (or nearly all) s/c patients. Studies have shown that early Vitamin D can greatly decrease the severity of symptoms and reduce deaths, but only if given very early in m/m phases. Dr Patterson developed testing that with blood work, can determine optimum timing, when to give a patient leronlimab. However, LL displays efficacy for m/m and for s/c so I'd like to learn more about Patterson's findings.
Dr Been has interviewed a doctor several times on youtube, who has treated hundreds of cv19 patients and is confident that timing is critical for administration of several of the treatments for cv19, eg steroids will have no effect and in fact can cause harm if given too early (8 days after first symptoms being optimum) but are very helpful if given after the 8 days.To say that some patients don't respond to LL, may be misleading, because timing might be the issue instead. Or timing could be the issue, "with some of the patients" who don't seem to respond to LL. Also, these patients may have responded if their initial dose was given by IV.

I'm a retired chemist, which is extremely different than a biologist or virologist. But I do appreciate detail, read and study things I don't understand, but often do understand enough about key points (eg MOA). It is unlikely that anybody reads substantially more than I do about cv19 treatments, although I often skip over alot of the details.