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Posted On: 04/15/2021 2:41:01 PM
Post# of 36541
The white paper has a lot of good things to say about li-Key...NGIO has great covid vaccine...let's hope we will be able to get lots funding to take it to the finish line. RADVAC.org is a non-profit org, so maybe they can get some funding and help GNBT/NGIO out...
RJS wrote -
“Readers of this publication will note that a Pan-DR Epitope peptide (PADRE) was utilized in this antigen surface presentation design. However, we have decided to use the Ii-key technology instead of the PADRE approach to enhance the T helper response for the following reason. Both PADRE and Ii-key appear to reduce MHC Class II binding affinity variability due to genetic variation. However, Ii-key allows the use of pathogen-derived epitopes, and potent MHC Class II epitopes of SARS-CoV-2 have been identified. Including these viral epitopes in a vaccine design instead of a non-viral epitope will provide better T helper response to infection by a closely related virus (e.g. SARS-CoV-2 mutants), since T memory cells will be cross-reactive to the coronavirus epitopes, but not to the PADRE epitope.”
Put “Ii-key” as a term in “find on page”.
https://radvac.org/wp-content/uploads/2021/03....pdf#page6
Read More: https://investorshangout.com/post/newpost/622...z6s8904OOT
RJS wrote -
“Readers of this publication will note that a Pan-DR Epitope peptide (PADRE) was utilized in this antigen surface presentation design. However, we have decided to use the Ii-key technology instead of the PADRE approach to enhance the T helper response for the following reason. Both PADRE and Ii-key appear to reduce MHC Class II binding affinity variability due to genetic variation. However, Ii-key allows the use of pathogen-derived epitopes, and potent MHC Class II epitopes of SARS-CoV-2 have been identified. Including these viral epitopes in a vaccine design instead of a non-viral epitope will provide better T helper response to infection by a closely related virus (e.g. SARS-CoV-2 mutants), since T memory cells will be cross-reactive to the coronavirus epitopes, but not to the PADRE epitope.”
Put “Ii-key” as a term in “find on page”.
https://radvac.org/wp-content/uploads/2021/03....pdf#page6
Read More: https://investorshangout.com/post/newpost/622...z6s8904OOT
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