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Posted On: 02/26/2021 7:35:05 AM
Post# of 148902
ibmiked,
The 60% likelihood of improvement is the clinical benefit/clinical significance.
p<0.05 (95% probability result is real/ 5% results due to chance) is the statistical significance.
As an example, remdesivir demonstrated with statistical significance their reduction in days to clinical resolution in mild and moderate patients (good p value), though the clinical benefit was very poor. (very large trial size = very low likelihood results due to chance). No reduction in mortality, respiratory failure, etc.
The 60% likelihood of improvement is the clinical benefit/clinical significance.
p<0.05 (95% probability result is real/ 5% results due to chance) is the statistical significance.
As an example, remdesivir demonstrated with statistical significance their reduction in days to clinical resolution in mild and moderate patients (good p value), though the clinical benefit was very poor. (very large trial size = very low likelihood results due to chance). No reduction in mortality, respiratory failure, etc.
Quote:
I'm confused, are they saying that they did not hit their p value because there is only 60% confidence versus the 95% confidence (p=.05) normally required for statistical significance?
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