Another perfect example... ALS is another blanket term for motor degenerative states.. LLMab may have an MOA that's helpful for some of the underlying issues that cause "sporadic ALS". Unfortunately, cases involving superoxide dismutase malformation / dysfunction or other cellular mechanisms will likely be unaffected.

https://www.nature.com/articles/ncpneuro0545

Bonus: SOD1 happens to be on chromosome 21 in humans, the one responsible for downs syndrome. Overexpression via trisomy is suspected to lead to widespread oxidative damage. Odds are high both of these can be safely crossed off the list of LLMab indications.