(Total Views: 338)
Posted On: 02/16/2021 1:33:55 PM
Post# of 145875
Havasu,
I believe the aviptadil trial indicates that the reversal of ARDS is a slow and gradual process. Immune restoration with leronlimab (or aviptadil) does not rapidly reverse the damage. Stopping further inflammation allows a gradual recovery.
I believe this is why the avidtadil effects were more evident in days 28-60 than 0-28, and arguably why the DSMB apparently saw a sign of additional placebo mortality in days 28-42.
I believe the aviptadil trial indicates that the reversal of ARDS is a slow and gradual process. Immune restoration with leronlimab (or aviptadil) does not rapidly reverse the damage. Stopping further inflammation allows a gradual recovery.
I believe this is why the avidtadil effects were more evident in days 28-60 than 0-28, and arguably why the DSMB apparently saw a sign of additional placebo mortality in days 28-42.
![](/m/images/thumb-up.png)
![](/m/images/thumb-down.png)