Remember every S/C patient started as mild; age and co morbid conditions may predict mortality but not necessarily progression, there have been young people become severe. If you watch and wait till someone becomes moderate you may have lost an important treatment window. If 10% mild are at high risk based on the assay. then treat them. that is precision medicine, giving to all patients, as suggested, is cave man medicine. How does this apply to LL? More vials sold. I was not soft peddling an assay.