smurph, a fairly simple non-viral car-t is making some inroads into solid tumors as well, and against the toxicity, persistence, and efficacy required to become main stream. PGEN has an overnight system showing real progress.

The simplicity of a drug like LL could be a real game changer. I am all about simple. All of this crazy gene editing keeps getting further into the weeds of complexity and that will not end well for most of them.

Simple will win.