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Posted On: 02/06/2021 10:54:10 AM
Post# of 148900
Potential combination with leronlimab? Maybe yes, maybe no.
KRAS-G12C increases cellular glucose uptake allowing tumors to grow rapidly. Their inhibitor downregulates the glucose uptake. Glucose uptake is regulated by CCL5 (RANTES) through mTORc. So how helpful their inhibitor would be depends on how well CCR5 regulates glucose uptake in comparison.
Glucose upregulation by CCL5 mentioned in a paper I have listed in this post -
https://investorshangout.com/post/view?id=5846283
KRAS-G12C increases cellular glucose uptake allowing tumors to grow rapidly. Their inhibitor downregulates the glucose uptake. Glucose uptake is regulated by CCL5 (RANTES) through mTORc. So how helpful their inhibitor would be depends on how well CCR5 regulates glucose uptake in comparison.
Glucose upregulation by CCL5 mentioned in a paper I have listed in this post -
https://investorshangout.com/post/view?id=5846283
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