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Posted On: 02/05/2021 2:38:04 AM
Post# of 148908
Re: chazzledazzle #76350
Like CD asked: do we have evidence of LL crossing an intact BBB? Virus infections can temporarily disrupt BBB integrity.
Is my memory right, that our only evidence of LL crossing the BBB was Sacha's study of an SHIV-compromised macaque? SHIV infection could disrupt the BBB, and LL could travel into the brain attached to a CCR5 receptor on an invading T cell.
So maybe LL can ride a T cell into the brain in many infections: HIV, covid, AD?)
Do we have direct evidence of LL crossing an intact BBB?
Is my memory right, that our only evidence of LL crossing the BBB was Sacha's study of an SHIV-compromised macaque? SHIV infection could disrupt the BBB, and LL could travel into the brain attached to a CCR5 receptor on an invading T cell.
So maybe LL can ride a T cell into the brain in many infections: HIV, covid, AD?)
Do we have direct evidence of LL crossing an intact BBB?
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