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Posted On: 02/05/2021 12:58:14 AM
Post# of 149270
Re: chazzledazzle #76368
The answer is effectively No. The reality is it may interact with other receptors, ligands, hormones, any number of extracellular structures... that would be extremely difficult question to quantify.
Follow up answer: I'm not aware of any MOA that isn't related to CCR5. I'll add the number of people who are homo- or heterozygous for d32 CCR5 mutations is a miniscule part of the population, and those that would have some disorder some as of yet undiscovered MOA of LLMab may help even more miniscule.
Follow up question: why was someone trying to make humans that would naturally survive a disease like this?
Follow up answer: I'm not aware of any MOA that isn't related to CCR5. I'll add the number of people who are homo- or heterozygous for d32 CCR5 mutations is a miniscule part of the population, and those that would have some disorder some as of yet undiscovered MOA of LLMab may help even more miniscule.
Follow up question: why was someone trying to make humans that would naturally survive a disease like this?
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