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In other words are cancers that dont overexpress CCR5 much less likely to metastasize?

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It looks like there's a good correlation between increased CCR5 and metastasis.

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Further, in cancers that don't have an overexpression of CCR5, would LL still be beneficial in tumor reduction and reducing the CCR5 expression from chemo?

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Even without overexpression there might be a slight benefit but it might be so slight to not be worthwhile to use.

Using leronlimab a few days before chemotherapy would stop the process of chemotaxis of CTCs and metastasis.