Quote:

---

I believe placebo group is less than 35%. The cd12 population specifically excludes the sickest of the sick on mechanical ventilation, which would have the highest mortality rate. So the 35% would need to be adjusted for this fact, but by how much, very difficult to tell.

CD12 Inclusion criteria:
3. Subject, if intubated, positive endexpiratory pressure (PEEP) <15 cmH2O with PaO2/FiO2 >150 mmHg.

---

Not quite right. The (PEEP) <15 cmH2O with PaO2/FiO2 >150 mmHg only applies to those with multiple organ failure.

Here's the inclusion criteria -

Evidence of critical illness, defined by at least 1 of the following:

AND
- Respiratory failure defined based on resource utilization requiring at least 1 of the following: Endotracheal intubation and mechanical ventilation, oxygen delivered by high-flow nasal cannula, noninvasive positive pressure ventilation, ECMO, or clinical diagnosis of respiratory failure (in setting of resource limitation)

OR

-Multiple organ dysfunction/failure

Subject, if intubated, positive endexpiratory pressure (PEEP) <15 cmH2O with PaO2/FiO2 >150 mmHg.