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Posted On: 01/24/2021 1:40:51 AM
Post# of 155592
Thanks that makes sense. I have no clue whatsoever on viscosity.
But I do know that one milliliter of water is 1000mg.
But it sounds like since leronlimab has super low viscosity, then you can make a one or two milliliter vial with perhaps as much as 35% leronlimab by weight. So no misprint in the paper.
Since its not a misprint, the chemotaxis experiment reported today in the Pestell paper seems a bit suspeicious.
The concentration of leronlimab in the fluid surrounding the possibly migrating cells is something like 35% leronlimab by weight.
That is just a massive amount of leronlimab. It could never be achieved inside of any animal.
Bloodstream levels would be 1000x lower.
I seem to remember reading other chemotaxis experiments that manage to inhibit chemotaxis with CCR5 blocker levels that are achieveable in the bloodstream of mammals. Maybe I am remembering maraviroc experiments?
But I do know that one milliliter of water is 1000mg.
But it sounds like since leronlimab has super low viscosity, then you can make a one or two milliliter vial with perhaps as much as 35% leronlimab by weight. So no misprint in the paper.
Since its not a misprint, the chemotaxis experiment reported today in the Pestell paper seems a bit suspeicious.
The concentration of leronlimab in the fluid surrounding the possibly migrating cells is something like 35% leronlimab by weight.
That is just a massive amount of leronlimab. It could never be achieved inside of any animal.
Bloodstream levels would be 1000x lower.
I seem to remember reading other chemotaxis experiments that manage to inhibit chemotaxis with CCR5 blocker levels that are achieveable in the bloodstream of mammals. Maybe I am remembering maraviroc experiments?
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