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The demand for mortality reducing therapeutics couldn't be higher. I think its easy for us to rationalize reasons why this may fail, but I would argue that in my lifetime (and perhaps the history of the human race) there has never been a larger imbalance between supply and demand for any product.

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Absolutely. We are sitting in a "perfect storm".

We get good data and we will go "up, up and away in our beautiful balloon".

The sight from up there will be beautiful as well.