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Posted On: 01/14/2021 2:51:01 PM
Post# of 145248
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Re: ClosetInvestor #72737
Quote:
If the 28 mortality endpoint was tending towards stat sig at 50%, the DSMC would’ve simply requested a 75% interim analysis and not specified to also see 42 day data.
Do you think the DSMC is doing things on a whim? They wouldn't ask for a 75% interim because just maybe on a coin flip it might make stat sig. They would only do so if there was a very good indication that 75% and 42 days would not only meet stat sig but would overcome the lower power of the lesser patient population.
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