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Posted On: 01/13/2021 6:08:59 PM
Post# of 145875
Yes, that's the main benefit I see. To prove that eliminating CCR5 cures covid.
But not the only benefit.
Recognition of CCR5 knockout as a cure or prophylaxis will drive investigation into whether and to what extent LL receptor occupancy can recapitulate that result.
Maybe if you achieve 95% receptor occupancy you get all the benefits of CCR5delta32.
Then all that's left is to find out how high to raise the dose and whether to use intravenous injection.
I would say the likelihood is very high that the current dosing scheme for covid is not correct.
First, if receptor occupancy is the key you should achieve that more quickly by injecting intravenously rather than subcutaneous.
And second of course is to increase the dose.
But not the only benefit.
Recognition of CCR5 knockout as a cure or prophylaxis will drive investigation into whether and to what extent LL receptor occupancy can recapitulate that result.
Maybe if you achieve 95% receptor occupancy you get all the benefits of CCR5delta32.
Then all that's left is to find out how high to raise the dose and whether to use intravenous injection.
I would say the likelihood is very high that the current dosing scheme for covid is not correct.
First, if receptor occupancy is the key you should achieve that more quickly by injecting intravenously rather than subcutaneous.
And second of course is to increase the dose.
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