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Posted On: 01/06/2021 5:31:30 PM
Post# of 148891
Disagree.
Keep in mind that they had about 30 patients on placebo only (out of ~90 without any SOC add-ons) in Spring before the protocol was changed to incorporate SOC add-ons... Not unrealistic that a lot of those died (e.g. 50%, which would already account for 15 events in the placebo group.
The worst distribution allowed to achieve stat sig would be ~37 deaths in placebo (28,4%), ~50 in LL arm (19,2%). That's about 33% RRR.
Not sure whether all those 87 deaths happened within the 28 days timeframe though.
Exciting 2-3 weeks ahead for sure
Keep in mind that they had about 30 patients on placebo only (out of ~90 without any SOC add-ons) in Spring before the protocol was changed to incorporate SOC add-ons... Not unrealistic that a lot of those died (e.g. 50%, which would already account for 15 events in the placebo group.
The worst distribution allowed to achieve stat sig would be ~37 deaths in placebo (28,4%), ~50 in LL arm (19,2%). That's about 33% RRR.
Not sure whether all those 87 deaths happened within the 28 days timeframe though.
Exciting 2-3 weeks ahead for sure
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