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Posted On: 01/05/2021 6:03:09 PM
Post# of 148908
"Thinning, Leaky Brain Blood Vessels Seen in COVID-19"
- NEJM, as reported in Medpage Today
I'm pretty sure we've been told endothelial cell inflammation is RANTES driven, so not a surprise to leronlimab followers. We know we also cross the BBB - can we fix this?
More from MPT:
"— High-resolution MRI shows injury and inflammation, but no direct viral attack
by Judy George, Senior Staff Writer, MedPage Today January 4, 2021
Microvascular brain injury was seen in COVID-19 patients who died, but no evidence of a direct viral attack on the brain was detected, a pathology report showed.
Damage caused by thinning and leaky brain blood vessels consistently appeared on high-resolution MRI, but there were no signs of SARS-CoV-2 infection in tissue samples, reported Avindra Nath, MD, clinical director of the National Institute of Neurological Disorders and Stroke (NINDS), and co-authors in a New England Journal of Medicine letter."
BTW, appreciate any insight on how we cross BBB. I do understand injury and inflammation can temporarily disrupt it - T-cells sometimes get in. Are we there riding on CCR5 receptors on T-cells?
- NEJM, as reported in Medpage Today
I'm pretty sure we've been told endothelial cell inflammation is RANTES driven, so not a surprise to leronlimab followers. We know we also cross the BBB - can we fix this?
More from MPT:
"— High-resolution MRI shows injury and inflammation, but no direct viral attack
by Judy George, Senior Staff Writer, MedPage Today January 4, 2021
Microvascular brain injury was seen in COVID-19 patients who died, but no evidence of a direct viral attack on the brain was detected, a pathology report showed.
Damage caused by thinning and leaky brain blood vessels consistently appeared on high-resolution MRI, but there were no signs of SARS-CoV-2 infection in tissue samples, reported Avindra Nath, MD, clinical director of the National Institute of Neurological Disorders and Stroke (NINDS), and co-authors in a New England Journal of Medicine letter."
BTW, appreciate any insight on how we cross BBB. I do understand injury and inflammation can temporarily disrupt it - T-cells sometimes get in. Are we there riding on CCR5 receptors on T-cells?
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