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Posted On: 01/04/2021 2:20:06 PM
Post# of 148936
Help, please, re: leron/lenzi comparison
I think I remember Patterson saying something like only 15% of Covid patients had elevated GM-CSF. Does that make sense given the results lenzi seems to be getting? Are there multiple other mechs that result in cytokine storm that don't involve GM-CSF?
Is this big picture correct:
- Elevated GM-CSF creates excess supply of macros/monos that can be trafficked into lungs; lenzi helps by stopping that "push" dynamic.
- Leron works on the other end: by cloaking all the CCR5 receptors on Ts/macros, those cells experience no "pull" from RANTES to migrate into the lungs/organs.
I think I remember Patterson saying something like only 15% of Covid patients had elevated GM-CSF. Does that make sense given the results lenzi seems to be getting? Are there multiple other mechs that result in cytokine storm that don't involve GM-CSF?
Is this big picture correct:
- Elevated GM-CSF creates excess supply of macros/monos that can be trafficked into lungs; lenzi helps by stopping that "push" dynamic.
- Leron works on the other end: by cloaking all the CCR5 receptors on Ts/macros, those cells experience no "pull" from RANTES to migrate into the lungs/organs.
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