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Posted On: 10/24/2020 11:38:22 PM
Post# of 148984
I can't believe they let the trial run with 22/23 so i have no clue on any of this.
But I do have some questions
How is the power calculated and what value is needed? All things being equal, how does the power change from 70% at 50% interim to 75% interim?
But most importantly, upon what authority can the DSMC authorize another interim analysis? Do they just do an interim analysis whenever they want? I thought that interim analyses and to be agreed upon with the FDA before the trial begins.
But I do have some questions
How is the power calculated and what value is needed? All things being equal, how does the power change from 70% at 50% interim to 75% interim?
But most importantly, upon what authority can the DSMC authorize another interim analysis? Do they just do an interim analysis whenever they want? I thought that interim analyses and to be agreed upon with the FDA before the trial begins.
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