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Posted On: 10/21/2020 9:36:11 PM
Post# of 148949
In case any of you weren’t really aware of the significance of crossing the blood brain barrier, here is an interesting article that has a few noteworthy nuggets like this:
“As discussed below, the transport of small molecules across the BBB is the exception rather than the rule, and 98% of all small molecules do not cross the BBB (FIG. 1). Moreover, all large-molecule products of biotechnology, such as monoclonal antibodies (mAbs), recombinant proteins, antisense, or gene therapeutics, do not cross the BBB (FIG. 1).“
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...11888title
“As discussed below, the transport of small molecules across the BBB is the exception rather than the rule, and 98% of all small molecules do not cross the BBB (FIG. 1). Moreover, all large-molecule products of biotechnology, such as monoclonal antibodies (mAbs), recombinant proteins, antisense, or gene therapeutics, do not cross the BBB (FIG. 1).“
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...11888title
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