When the board is set up isn’t it Cytodyn that gives them their marching orders? Tells them the what and the how? Obviously they are analyzing the exact primary and secondary endpoints, as well as safety, and those numbers will be cut and dry. I mean aren’t their recommendations based on what Cytodyn specifies? So even though they won’t know the exact p-value they’d know it is at least X or Y if the board recommends one of the preset paths? Like, wouldn’t Cytodyn specify that “if p-value falls between X and Y the recommendation should be this. And if this secondary measure shows X the recommendations should be this.” Basically giving them a variety of indications that stopping or unblinding would be worthwhile? Or not worthwhile, of course.

If that’s the case, and I honestly don’t know if it is, they’d be able to make some important decisions even though they don’t have the exact value.