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Posted On: 10/08/2020 8:28:44 AM
Post# of 154483
Interesting discussion on p-values.
We are arguing here the possibilities of hitting a very low p-number for trial stoppage.
Rightly so.
In my calculation (binomial). I have for, say, 25/20 (deaths LL/SOC) a p-value of 0.0844.
This will no qualify for end-point statistical significance, and less for interim stoppage.
However, 25/20 mean 19.2% and 30.8% of total deaths respectively.
This means 37.66% REDUCTION of deaths from SOC to Leronlimab. Or, putting it in another way: of every 100 patients there will be approximately 38 lives saved (37.66 more exactly).
FDA, let me ask you a question: can you not just approve immediately a drug than can save the life of 38 out of every 100 people ???
We are in a Pandemic for Pete's sake !!!. FDA: let me help you with the math, from 212000 current deaths 80500 would have been saved !!!!
Approve Leronlimab pronto
Please note: we might (and probably will) "hit" a better p-value than 0.0844. This is just a discussion on p-values larger than potential interim stoppage levels (<0.005 ?).
We are arguing here the possibilities of hitting a very low p-number for trial stoppage.
Rightly so.
In my calculation (binomial). I have for, say, 25/20 (deaths LL/SOC) a p-value of 0.0844.
This will no qualify for end-point statistical significance, and less for interim stoppage.
However, 25/20 mean 19.2% and 30.8% of total deaths respectively.
This means 37.66% REDUCTION of deaths from SOC to Leronlimab. Or, putting it in another way: of every 100 patients there will be approximately 38 lives saved (37.66 more exactly).
FDA, let me ask you a question: can you not just approve immediately a drug than can save the life of 38 out of every 100 people ???
We are in a Pandemic for Pete's sake !!!. FDA: let me help you with the math, from 212000 current deaths 80500 would have been saved !!!!
Approve Leronlimab pronto
Please note: we might (and probably will) "hit" a better p-value than 0.0844. This is just a discussion on p-values larger than potential interim stoppage levels (<0.005 ?).
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