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Posted On: 09/10/2020 5:10:00 PM
Post# of 148988
There has been a hypothesis put forward in regards to bradykinin storms being responsible for COVID symptoms (as opposed to cytokine storms). This was first posed by a paper published in E-Life sciences (referenced below).
Bradykinin hypothesis' may explain how COVID-19 attacks the human body
https://www.ctvnews.ca/health/coronavirus/bra...-1.5089712
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm https://elifesciences.org/articles/59177
The article below: Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors Implications for HIV-1 co-receptor function.
https://febs.onlinelibrary.wiley.com/doi/pdf/...99.00553.x
The interesting fact mentioned in this paper is that bradykinin receptor (BRB2) is, similar to CCR5, capable of mediating M-tropic HIV-1 entry.
Why is this important ??? The paper demonstrates that there are lots of common environmental patterns between GPCRs (G-protein coupled receptor) and CRs most specifically between BRB2 (bradykinin receptor) and CCR5).
Therefore, in the case bradykinin storm is responsible, Leronlimab is likely to work given the similarity between the receptors.
A good read for the weekend.
Bradykinin hypothesis' may explain how COVID-19 attacks the human body
https://www.ctvnews.ca/health/coronavirus/bra...-1.5089712
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm https://elifesciences.org/articles/59177
The article below: Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors Implications for HIV-1 co-receptor function.
https://febs.onlinelibrary.wiley.com/doi/pdf/...99.00553.x
The interesting fact mentioned in this paper is that bradykinin receptor (BRB2) is, similar to CCR5, capable of mediating M-tropic HIV-1 entry.
Why is this important ??? The paper demonstrates that there are lots of common environmental patterns between GPCRs (G-protein coupled receptor) and CRs most specifically between BRB2 (bradykinin receptor) and CCR5).
Therefore, in the case bradykinin storm is responsible, Leronlimab is likely to work given the similarity between the receptors.
A good read for the weekend.
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