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Posted On: 09/09/2020 1:33:29 AM
Post# of 153903
Havasu, you asked about a mouse study I posted yesterday.
I posted about two studies about mouse disease, both about neuroinflammation and Huntington's Disease. One was this one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370188/
:CCR5KO in the following means CCR5 Knock Out -- the focus of the article:
"Of note, the five highest scoring canonical pathways each for CCR5WT-specific and CCR5WT/KO common gene sets all belonged in the categories of immune system and inflammation (Fig. 4A–J). Notably, two of the five canonical pathways affected by differential gene expression specific to CCR5WT explicitly implicated macrophages in gp120-associated neuronal injury and behavioral impairment (Fig. 4A and E). One pathway was specifically CCR5 signaling in macrophages. In contrast, CCR5KO-specific regulated pathways mapped to the nervous system, namely the γ-amino butyric acid (GABA) neurotransmission system and Huntington’s Disease (HD, Fig. 4K and N), to basic physiological mechanisms (Fig. 4M and O) and one inflammation-related pathway (Fig. 4L)."
This was the other
https://www.jneurosci.org/content/28/13/3277
"In line with the above findings, elevated cytosolic CCL5/RANTES levels were also observed in the brains of two mouse models of HD [R6/2 and Hdh(CAG)150] and human HD patients."
I posted about two studies about mouse disease, both about neuroinflammation and Huntington's Disease. One was this one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370188/
:CCR5KO in the following means CCR5 Knock Out -- the focus of the article:
"Of note, the five highest scoring canonical pathways each for CCR5WT-specific and CCR5WT/KO common gene sets all belonged in the categories of immune system and inflammation (Fig. 4A–J). Notably, two of the five canonical pathways affected by differential gene expression specific to CCR5WT explicitly implicated macrophages in gp120-associated neuronal injury and behavioral impairment (Fig. 4A and E). One pathway was specifically CCR5 signaling in macrophages. In contrast, CCR5KO-specific regulated pathways mapped to the nervous system, namely the γ-amino butyric acid (GABA) neurotransmission system and Huntington’s Disease (HD, Fig. 4K and N), to basic physiological mechanisms (Fig. 4M and O) and one inflammation-related pathway (Fig. 4L)."
This was the other
https://www.jneurosci.org/content/28/13/3277
"In line with the above findings, elevated cytosolic CCL5/RANTES levels were also observed in the brains of two mouse models of HD [R6/2 and Hdh(CAG)150] and human HD patients."
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